Demecolceine

• Catalog No.: D230750
• CAS Number: 518-11-6
• M. F.: C20H23NO5
• M. W.: 357.40032
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (10S)-14-hydroxy-3,4,5-trimethoxy-10-(methylamino)tricyclo[9.5.0.0^2,^7]hexadeca-1(16),2,4,6,11,14-hexaen-13-one
• IUPAC Traditional name: (10S)-14-hydroxy-3,4,5-trimethoxy-10-(methylamino)tricyclo[9.5.0.0^2,^7]hexadeca-1(16),2,4,6,11,14-hexaen-13-one
• Synonyms: (7S)-6,7-Dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one; NSC 36559; N-Desacetyl-N-methylcolchiceine; 7-Deacetamido-7-(methylamino)colchiceine

DATABASE IDS

• CAS Number: 518-11-6

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: 120-122°C
• Solubility: Dichlormethane
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pa

REFERENCES

• Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992)
• Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1992)
• Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1992)
• Andreu, J.M., et al.: Biochemistry, 37, 8356 (1992)
• Jordan, A., et al.: Med. Res. Rev