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11-Dehydro Thromboxane B2_Molecular_structure_CAS_67910-12-7)
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11-Dehydro Thromboxane B2

Catalog No. D230555 Name Toronto Research Chemicals
CAS Number 67910-12-7 Website http://www.trc-canada.com
M. F. C20H32O6 Telephone +1 (416) 665-9696
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SYNONYMS

IUPAC name
(5Z)-7-[(2R,3S,4S)-4-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-6-oxooxan-3-yl]hept-5-enoic acid
IUPAC Traditional name
11-dehydro-thromboxane
Synonyms
[2R-[2α(1E,3S*),3β(Z),4β]]-7-[Tetrahydro-4-hydroxy-2-(3-hydroxy-1-octenyl)-6-oxo-2H-pyran-3-yl] 5-Heptenoic Acid
11-Dehydro-TXB2
(5Z)-7-[(2R,3S,4S)-Tetrahydro-4-hydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-6-oxo-2H-pyran-3-yl]-5-heptenoic Acid
(5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxo-thromboxa-5,13-dien-1-oic Acid
11-keto-Thromboxane B2

DATABASE IDS

CAS Number 67910-12-7

PROPERTIES

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DETAILS

Description (English)
A metabolite of Thromboxane that is an in vivo markers of oxidative stress and platelet activation. It is associated with adverse cardiovascular events in Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT).

REFERENCES

  • Santilli, F. et al.: J. Am. Coll. Cardiol., 47, 391 (2006)
  • Montine, T.J. et al.: PLoS One, 5, No pp given (2006)
  • Boehm, E. et al.: J. Biol. Chem., 279, 7663 (2006)