Daunorubicinol (Mixture of Diastereomers)

• Catalog No.: D194510
• M. F.: C27H31NO10
• M. W.: 529.53574
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-[(1R)-1-hydroxyethyl]-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione
• IUPAC Traditional name: dihydrodaunomycin
• Synonyms: Leukaemomycin D; 13-Dihydrodaunorubicin; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-[1-hydroxyethyl]-1-methoxy-5,12-naphthacenedione; Duborimycin

PROPERTIES

• Apperance: Red Solid
• Melting Point: 179-181°C
• Solubility: Chloroform
• Solubility: Dichloromethane
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A metabolite of Daunorubicin. Used as an antineoplastic. Complexes with DNA. Inhibits DNA and RNA synthesis.

REFERENCES

• Mizuno, N.S., et al.: Cancer Res., 35, 1542 (1975)
• Munger, C., et al.: Cancer Res., 48, 2404 (1975)
• Kobayashi, Y., et al.: J. Biol. Chem., 275, 17639 ( 2000), Burke, B., et al.: Cardiovasc. Toxicol., 2, 41 (1975)