Darunavir

• Catalog No.: D193500
• CAS Number: 206361-99-1
• M. F.: C27H37N3O7S
• M. W.: 547.66358
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-3-hydroxy-4-[N-(2-methylpropyl)4-aminobenzenesulfonamido]-1-phenylbutan-2-yl]carbamate
• IUPAC Traditional name: darunavir
• Synonyms: TMC-114; [(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenyl-methyl)propyl]carabamic Acid (3R,3aS,6aR)-Hexahydrofuro[2,3-b]-furan-3-yl Ester; UIC-94017

DATABASE IDS

• CAS Number: 206361-99-1

PROPERTIES

• Apperance: Off-White to Pale Yellow Solid
• Melting Point: 130-132°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral.

REFERENCES

• Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003)
• Arasteh, K., et al.: AIDS, 19, 943 (2003)
• Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2003)