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Demecolcine Hydrobromide Salt_Molecular_structure_CAS_1246817-95-7)
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Demecolcine Hydrobromide Salt

Catalog No. D230795 Name Toronto Research Chemicals
CAS Number 1246817-95-7 Website http://www.trc-canada.com
M. F. C21H26BrNO5 Telephone +1 (416) 665-9696
M. W. 452.33884 Fax +1 (416) 665-4439
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Storage Chembase ID: 165387

SYNONYMS

IUPAC name
(10S)-3,4,5,14-tetramethoxy-10-(methylamino)tricyclo[9.5.0.02,7]hexadeca-1(16),2,4,6,11,14-hexaen-13-one hydrobromide
IUPAC Traditional name
colcemid hydrobromide
Synonyms
N-Desacetyl-N-methylcolchicine Hydrobromide Salt
(7S)-6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one Hydrobromide

DATABASE IDS

CAS Number 1246817-95-7

PROPERTIES

Certificate of Analysis Download
Apperance White Solid
Solubility Dichlormethane
Solubility DMSO
Solubility Methanol
MSDS Link Download

DETAILS

Description (English)
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pa

REFERENCES

  • Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992)
  • Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1992)
  • Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1992)
  • Andreu, J.M., et al.: Biochemistry, 37, 8356 (1992)
  • Jordan, A., et al.: Med. Res. Rev