Cyclosporin B-d4

• Catalog No.: C988904
• M. F.: C33H64N4O5
• M. W.: 596.88506

SYNONYMS

• IUPAC name: (2R,6R,7R,9E)-2-(butylamino)-5-(dimethylamino)-6-hydroxy-7-methyl(10,11,11,11-^2H₄)undec-9-ene-3,4-dione; (2S)-4-methyl-N-[(3S)-2-methyl-4-oxoheptan-3-yl]-2-(methylamino)pentanamide
• IUPAC Traditional name: (2R,6R,7R,9E)-2-(butylamino)-5-(dimethylamino)-6-hydroxy-7-methyl(10,11,11,11-^2H₄)undec-9-ene-3,4-dione; (2S)-4-methyl-N-[(3S)-2-methyl-4-oxoheptan-3-yl]-2-(methylamino)pentanamide
• Synonyms: Antibiotic S 7481F2-d4; Ala2-cyclosporine-d4

DETAILS

Description (English)

An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.

REFERENCES

• van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988)
• Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (1988)
• Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (1988)