Cyclosporin A-13C2,d4 (Major)

• Catalog No.: C988901
• M. F.: C32H65N3O4
• M. W.: 557.86150968
• Storage: Refrigerator

SYNONYMS

• IUPAC name: (2S)-N-[(1S)-1-{[(5R,6R,8E)-5-hydroxy-6-methyl-3-oxo(9,10-^1^3C₂,9,10,10,10-^2H₄)dec-8-en-4-yl](methyl)carbamoyl}-2-methylpropyl]-4-methyl-2-(methylamino)pentanamide; bis(butane)
• IUPAC Traditional name: (2S)-N-[(1S)-1-{[(5R,6R,8E)-5-hydroxy-6-methyl-3-oxo(9,10-^1^3C₂,9,10,10,10-^2H₄)dec-8-en-4-yl](methyl)carbamoyl}-2-methylpropyl]-4-methyl-2-(methylamino)pentanamide; bis(butane)
• Synonyms: Sandimmun(e)-13C2,d4; Optimmune-13C2,d4; Ciclosporin-13C2,d4; Cyclosporine-13C2,d4; Atopica-13C2,d4; Neoral-13C2,d4; Restasis-13C2,d4

PROPERTIES

• Apperance: White Solid
• Melting Point: 140-145°C
• Solubility: Acetone
• Solubility: Benzene
• Solubility: Chloroform
• Solubility: Ethanol
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.

REFERENCES

• van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988)
• Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (1988)
• Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (1988)