Cyclophosphamide-d4

• Catalog No.: C988582
• CAS Number: 173547-45-0
• M. F.: C7H15Cl2N2O2P
• M. W.: 261.085961
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 2-[bis(2-chloroethyl)amino](4,4,5,5-^2H₄)-1,3,2λ^5-oxazaphosphinan-2-one
• IUPAC Traditional name: 2-[bis(2-chloroethyl)amino](4,4,5,5-^2H₄)-1,3,2λ^5-oxazaphosphinan-2-one
• Synonyms: Genoxal-d4; N,N-Bis(2-chloroethyl)tetrahydro-4,5-d2-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide; Cytoxan-d4; NSC 26271-d4; Cycloblastin-d4; Endoxan-d4; Cyclostin-d4; Hexadrin-d4; Mitoxan-d4

DATABASE IDS

• CAS Number: 173547-45-0

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 41-45°C
• Solubility: Alcohol
• Solubility: Benzene
• Solubility: Chloroform
• Solubility: Dioxane
• Solubility: Ethylene Glycol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This sub

REFERENCES

• Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962)
• Fraiser, L.H., et al.: Drugs, 42, 781 (1962)
• Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1962)