Cyclopamine

• Catalog No.: C988400
• CAS Number: 4449-51-8
• M. F.: C27H41NO2
• M. W.: 411.61994
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethyl-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3'H-spiro[cyclohexa[a]fluorene-9,2'-furo[3,2-b]pyridine]-3-ol
• IUPAC Traditional name: (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethyl-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a-hexadecahydro-1H,3'H-spiro[cyclohexa[a]fluorene-9,2'-furo[3,2-b]pyridine]-3-ol
• Synonyms: 11-Deoxyjervine; (3β,23β)-17,23-Epoxyveratraman-3-ol; 11-deoxojervine; (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol

DATABASE IDS

• CAS Number: 4449-51-8

PROPERTIES

• Apperance: White Solid
• Melting Point: 236-238°C
• Solubility: Chloroform
• Solubility: DMSO (1mg/200 μL
• Solubility: heated to 70°C)
• Solubility: Hot Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Cyclopamine antibacterial properties. Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.Solubility: 1mg of Cyclopamine dissolves in 0.2ml DMSO with heating to approximate

REFERENCES

• Kanda, S., et al.: J. Biol. Chem., 278,10, 8244 (2003)
• Rao, et al.: Development, 130, 1549 (2003)
• Taipale, J., et al. Nature 406, 1005 (2003)
• Perron, M., et al. Development 130, 1565 (2003)
• Watkins, D.N., et al.: Nature, 422, 313 (2003)