Cyanine-3 Cyclopamine Potassium Salt

• Catalog No.: C959300
• M. F.: C60H81KN4O9S2
• M. W.: 1105.53484
• Storage: Refrigerator

SYNONYMS

• IUPAC name: potassium 1-[5-({2-[(3S,3'R,3'aS,7'aR)-3-hydroxy-3',6',10,11b-tetramethyl-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3'H-spiro[cyclohexa[a]fluorene-9,2'-furo[3,2-b]pyridine]-4'-yl]ethyl}carbamoyl)pentyl]-2-[(1E)-3-[(2E)-1-ethyl-3,3-dimethyl-5-sulfonato-2,3-dihydro-1H-indol-2-ylidene]prop-1-en-1-yl]-3,3-dimethyl-3H-indol-1-ium-5-sulfonate
• IUPAC Traditional name: potassium 1-[5-({2-[(3S,3'R,3'aS,7'aR)-3-hydroxy-3',6',10,11b-tetramethyl-2,3,3',3'a,4,5',6,6',6a,6b,7,7',7'a,8,11,11a-hexadecahydro-1H-spiro[cyclohexa[a]fluorene-9,2'-furo[3,2-b]pyridine]-4'-yl]ethyl}carbamoyl)pentyl]-2-[(1E)-3-[(2E)-1-ethyl-3,3-dimethyl-5-sulfonatoindol-2-ylidene]prop-1-en-1-yl]-3,3-dimethylindol-1-ium-5-sulfonate
• Synonyms: Cy-3-Cyclopamine Potassium Salt

PROPERTIES

• Apperance: Brown Solid
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

A fluorescent deriviative of Cyclopamine, which demonstrates teratogenic properties and has been shown to reverse effects ofoncogenic mutations in Smoothened and Patched.1

REFERENCES

• Taipale, J., et al. Nature 406, 1005 (2000)
• Perron, M., et al. Development 130, 1565 (2003)