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Crizotinib-d4
Catalog No.	C785002	Name	Toronto Research Chemicals
CAS Number		Website	http://www.trc-canada.com
M. F.	C16H18N2O3	Telephone	+1 (416) 665-9696
M. W.	286.32572	Fax	+1 (416) 665-4439
Purity		Email	info@trc-canada.com
Storage		Chembase ID: 165036

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SYNONYMS

IUPAC name

(3R,4S)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydro-2H-1-benzopyran-6-carbonitrile

IUPAC Traditional name

cromakalim

Synonyms

[3-[[(R)-1-(2,6-Dichloro-3-fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl-d4)-1H-pyrazol-4-yl]pyridin-2-yl]amine

PF 02341066-d4

3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl-d4)-1H-pyrazol-4-yl]-2-pyridinamine

(R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl-d4)-1H-pyrazol-4-yl]pyridin-2-ylamine

PF 2341066-d4

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PROPERTIES

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DETAILS

Description (English)

Labelled Crizotinib(C78500). A potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.

REFERENCES

Zou, H.Y. et al.: Cancer Res., 67, 4408 (2007)
Cui, J.J. et al.: J. Med. Chem., No pp given (2007)
Sasaki, T. et al.: Cancer. Res. et al.: 70, 10038 (2007)