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Crizotinib

Catalog No. C785000 Name Toronto Research Chemicals
CAS Number 877399-52-5 Website http://www.trc-canada.com
M. F. C21H22Cl2FN5O Telephone +1 (416) 665-9696
M. W. 450.3366832 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Refrigerator Chembase ID: 165035

SYNONYMS

IUPAC name
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-{1-[(2,2,6,6-2H4)piperidin-4-yl]-1H-pyrazol-4-yl}pyridin-2-amine
IUPAC Traditional name
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-{1-[(2,2,6,6-2H4)piperidin-4-yl]pyrazol-4-yl}pyridin-2-amine
Synonyms
PF 02341066
(R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylamine
PF 2341066
3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
[3-[[(R)-1-(2,6-Dichloro-3-fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-yl]amine

DATABASE IDS

CAS Number 877399-52-5

PROPERTIES

Certificate of Analysis Download
Apperance White Solid
Melting Point 202-204°C
Solubility DMSO
Solubility Methanol
MSDS Link Download
Storage Condition Refrigerator

DETAILS

Description (English)
Crizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.

REFERENCES

  • Zou, H.Y. et al.: Cancer Res., 67, 4408 (2007)
  • Cui, J.J. et al.: J. Med. Chem., No pp given (2007)
  • Sasaki, T. et al.: Cancer. Res. et al.: 70, 10038 (2007)