Crizotinib

• Catalog No.: C785000
• CAS Number: 877399-52-5
• M. F.: C21H22Cl2FN5O
• M. W.: 450.3366832
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-{1-[(2,2,6,6-^2H₄)piperidin-4-yl]-1H-pyrazol-4-yl}pyridin-2-amine
• IUPAC Traditional name: 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-{1-[(2,2,6,6-^2H₄)piperidin-4-yl]pyrazol-4-yl}pyridin-2-amine
• Synonyms: PF 02341066; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylamine; PF 2341066; 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine; [3-[[(R)-1-(2,6-Dichloro-3-fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-yl]amine

DATABASE IDS

• CAS Number: 877399-52-5

PROPERTIES

• Apperance: White Solid
• Melting Point: 202-204°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

Crizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.

REFERENCES

• Zou, H.Y. et al.: Cancer Res., 67, 4408 (2007)
• Cui, J.J. et al.: J. Med. Chem., No pp given (2007)
• Sasaki, T. et al.: Cancer. Res. et al.: 70, 10038 (2007)