Crenolanib Trifluoroacetic Acid Salt

• Catalog No.: C781800
• CAS Number: 670220-88-9
• M. F.: C13H16O7
• M. W.: 284.26194

SYNONYMS

• IUPAC name: (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(2-methylphenoxy)oxane-2-carboxylic acid
• IUPAC Traditional name: (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(2-methylphenoxy)oxane-2-carboxylic acid
• Synonyms: CP 868596 Trifluoroacetic Acid Salt; [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine Trifluoroacetic Acid Salt; ARO 002 Trifluoroacetic Acid Salt; 1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine Trifluoroacetic Acid Salt

DATABASE IDS

• CAS Number: 670220-88-9

DETAILS

Description (English)

Crenolanib (CP-868569) is a tyrosine kinase inhibitor that acts by specifically inhibiting the receptor tyrosine kinases PDGFRα and PDGFRβ. Crenolanib (CP-868569) inhibits the activity of PDGFRα D842V kinase and prevented the phosphorylation of wild type

REFERENCES

• Michael, M. et al.: Br. J. Cancer, 103, 1554 (2010)
• Lewis, N.L. et al.: J. Clin. Oncol., 27, 5262 (2010)