CP-154526 Hydrochloride

• Catalog No.: C781295
• CAS Number: 257639-98-8
• M. F.: C23H33ClN4
• M. W.: 400.98792
• Storage: Refrigerator

SYNONYMS

• IUPAC name: N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
• IUPAC Traditional name: N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
• Synonyms: CP 154526 Hydrochloride; N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Hydrochloride

DATABASE IDS

• CAS Number: 257639-98-8

PROPERTIES

• Solubility: Methanol
• Apperance: Pale Yellow Solid
• Melting Point: 167-169°C
• Solubility: DMSO
• Storage Condition: Refrigerator

DETAILS

Description (English)

A selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1). It blocks CRF-induced adenylate cyclase activation and attenuates activation of the HPA axis by CRF. It displayed anxiolytic-like activity in the rat elevated plus-maz

REFERENCES

• Lundkist, J. et al.: Eur. J. Pharmacol., 309, 195 (1996)
• Arbolius, L. et al.: J. pharmacol. Exp. Therap., 294, 588 (1996)
• Kehne, J.H. et al.: Neuropharmacol., 39, 1357 (1996)