CP-100356 Hydrochloride

• Catalog No.: C781250
• CAS Number: 142715-48-8
• M. F.: C31H37ClN4O6
• M. W.: 597.10168
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxyquinazolin-2-amine hydrochloride
• IUPAC Traditional name: 4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxyquinazolin-2-amine hydrochloride
• Synonyms: 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine monohydrochloride

DATABASE IDS

• CAS Number: 142715-48-8

PROPERTIES

• Apperance: Off-White to Light Tan Solid
• Melting Point: 210-212°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356

REFERENCES

• Ayrton, A., et al.: Xenobiotica, 31, 469 (2001)
• Mizuno, N., et al.: Pharmacol. Rev., 55, 425 (2001)
• Fojo, T., et al.: Clin. Breast Cancer, 7, 749 (2001)
• Polli, J., et al.: Drug Metab. Dispos., 36, 695 92008),