CP-690550 Citrate (Tofacitinib Citrate)

• Catalog No.: C781351
• CAS Number: 540737-29-9
• M. F.: C26H33NO4
• M. W.: 423.54452
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 2-methyl-2-{3-[(3S)-1-{2-[4-(propan-2-yl)phenyl]acetyl}piperidin-3-yl]phenoxy}propanoic acid
• IUPAC Traditional name: 2-{3-[(3S)-1-[2-(4-isopropylphenyl)acetyl]piperidin-3-yl]phenoxy}-2-methylpropanoic acid
• Synonyms: CP 690500-10; (3R,4R)-1-(Cyanoacetyl)-4-methyl-N-methyl-N-1H-pyrrolo[2,3-d]pyrimidin-4-yl-3-piperidinamine 2-Hydroxy-1,2,3-propanetricarboxylate; Tofacitinib Citrate; (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile; 2-Hydroxy-1,2,3-propanetricarboxylate; CP 690550-10

DATABASE IDS

• CAS Number: 540737-29-9

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 198-202°C (dec.)
• Solubility: DMSO
• Solubility: Water
• Storage Condition: Refrigerator

DETAILS

Description (English)

CP-690550 is a pyrrolo[2,3-d]pyrimidine derivative, as Janus kinase inhibitor for treatment of rheumatoid arthritis.

REFERENCES

• Sheiner, L., et al.: Clin. Pharmacol. Ther., 25, 358 (1979)
• Dayneka, N., et al.: J. Pharmacokin. Biopharm., 21, 457 (1979)
• Changelian, P., et al.: Science, 302, 875 (1979)
• Lee, H., et al.: Clin. Pharmacol. Ther., 73, 348 (1979)
• Hutmacher, M., et al.: