Colchicine Methanethiosulfonate

• Catalog No.: C640030
• CAS Number: 1217821-52-7
• M. F.: C24H29NO8S2
• M. W.: 523.61896
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 3-(methanesulfonylsulfanyl)-N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl]propanamide
• IUPAC Traditional name: 3-(methanesulfonylsulfanyl)-N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl]propanamide

DATABASE IDS

• CAS Number: 1217821-52-7

PROPERTIES

• Apperance: Light Yellow Solid
• Melting Point: 119-120°C
• Solubility: Chloroform
• Solubility: Dichloromethane
• Solubility: DMF
• Solubility: DMSO
• Solubility: Ethanol
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

The methanethiosulfonate derfivative of Colchicine (C640000), an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several norma

REFERENCES

• Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992)
• Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1992)
• Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1992)
• Andreu, J.M., et al.: Biochemistry, 37, 8356 (1992)
• Jordan, A., et al.: Med. Res. Rev