iso-Colchicine-d3

• Catalog No.: C640006
• M. F.: C22H25NO6
• M. W.: 399.437

SYNONYMS

• IUPAC name: N-[(10S)-3,4,5,13-tetramethoxy-14-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(11),2(7),3,5,12,15-hexaen-10-yl](^2H₃)acetamide
• IUPAC Traditional name: N-[(10S)-3,4,5,13-tetramethoxy-14-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(11),2(7),3,5,12,15-hexaen-10-yl](^2H₃)acetamide
• Synonyms: N-[(7S)-5,6,7,10-Tetrahydro-1,2,3,9-tetramethoxy-10-oxobenzo[a]heptalen-7-yl]acetamide; Isocolchicine

PROPERTIES

• Apperance: Faintly Yellow Crystalline Powder
• Melting Point: 148-153°C

DETAILS

Description (English)

An isotopically labelled antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the

REFERENCES

• Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992)
• Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1992)
• Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1992)
• Andreu, J.M., et al.: Biochemistry, 37, 8356 (1992)
• Jordan, A., et al.: Med. Res. Rev