Colchicine-d6

• Catalog No.: C640003
• M. F.: C22H25NO6
• M. W.: 399.437
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: N-[(10S)-14-(^2H₃)methoxy-3,4,5-trimethoxy-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl](^2H₃)acetamide
• IUPAC Traditional name: N-[(10S)-14-(^2H₃)methoxy-3,4,5-trimethoxy-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl](^2H₃)acetamide
• Synonyms: NSC 757-d6; Colsaloid-d6; Condylon-d6; Colchineos-d6; N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide-d6; (-)-Colchicine-d6; Colchisol-d6; Colcin-d6

PROPERTIES

• Apperance: Light-Yellow Solid
• Melting Point: 153-155°C
• Solubility: Chloroform
• Solubility: Dichloromethane
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

An isotopically labelled antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the

REFERENCES

• Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992)
• Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1992)
• Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1992)
• Andreu, J.M., et al.: Biochemistry, 37, 8356 (1992)
• Jordan, A., et al.: Med. Res. Rev