Clasto-lactacystin(Omuralide)

• Catalog No.: C562500
• CAS Number: 154226-60-5
• M. F.: C10H15NO4
• M. W.: 213.2304
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (1R,4R,5S)-1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
• IUPAC Traditional name: (1R,4R,5S)-1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
• Synonyms: Clasto-lactacystin β-Lactone; (1R,4R,5S)-1-[(1S)-1-Hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione; Omuralide

DATABASE IDS

• CAS Number: 154226-60-5

PROPERTIES

• Apperance: White Solid
• Melting Point: 186-187°C
• Solubility: DMF
• Solubility: Ethanol
• Solubility: Hot Ethyl Acetate
• Solubility: Methanol
• Solubility: Pyridine
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induce

REFERENCES

• Craiu, A., et al.: J. Biol. Chem., 272, 13437 (1997)
• Dick, G.L.R., et al.: J. Biol. Chem., 272, 182 (1997)
• Fenteany, G. and Schreiber, S.: J. Biol. Chem., 273, 8545 (1997)
• Corey, E.J., et al.: J.A.C.S., 120, 2330 (1998)