2-Chloro-5-nitro-N-4-phenylbenzamide

• Catalog No.: C374050
• CAS Number: 22978-25-2
• M. F.: C13H9ClN2O3
• M. W.: 276.67516

SYNONYMS

• IUPAC name: 2-chloro-5-nitro-N-phenylbenzamide
• IUPAC Traditional name: 2-chloro-5-nitrobenzanilide
• Synonyms: GW9662

DATABASE IDS

• CAS Number: 22978-25-2

PROPERTIES

• Apperance: Off-White Solid
• Solubility: DMSO

DETAILS

Description (English)

A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 μM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 μM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-a (LXRa), retinoic acid receptor (RAR), retinoid X receptor-a (RXRa) and thyroid receptors a and b (TRa and TRb)

REFERENCES

• Huang, J.T., et al.: Nature, 400, 378 (1999)
• Wilson, T.M., et al.: J. Med. Chem., 43, 527 (1999)
• Leesnitzer, L.M., et al.: Biochemistry, 41, 6640 (2002)