4-Chloro Kynurenine-13C2,15N

• Catalog No.: C366942
• M. F.: C10H11ClN2O3
• M. W.: 245.63765857
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: 2-amino-4-(2-amino-4-chlorophenyl)-4-oxo(1,2-^1^3C₂)butanoic acid
• IUPAC Traditional name: 2-amino-4-(2-amino-4-chlorophenyl)-4-oxo(1,2-^1^3C₂)butanoic acid
• Synonyms: (+/-)-AV-101-13C2,15N; (+/-)-α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid-13C2,15N; α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid-13C2,15N; 4-Cl-KYN-13C2,15N

PROPERTIES

• Apperance: Pale Yellow Solid
• Melting Point: >205°C (dec.)
• Solubility: Aqueous Acid
• Solubility: Aqueous Base
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.

REFERENCES

• Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994)
• Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (1994)
• Palmer, G., et al.: Curr. Drug Targets, 2, 241 (1994)
• Wu, H., et al.: Exp. Neurol., 177, 222 (1994)