4-Chloro Kynurenine

• Catalog No.: C366940
• CAS Number: 75802-84-5
• M. F.: C10H11ClN2O3
• M. W.: 242.65894

SYNONYMS

• IUPAC name: 2-amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid
• IUPAC Traditional name: 2-amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid
• Synonyms: (+/-)-AV-101; α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid; (+/-)-α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid; 4-Cl-KYN

DATABASE IDS

• CAS Number: 75802-84-5

DETAILS

Description (English)

7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.

REFERENCES

• Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994)
• Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (1994)
• Palmer, G., et al.: Curr. Drug Targets, 2, 241 (1994)
• Wu, H., et al.: Exp. Neurol., 177, 222 (1994)