Cloticasone Propionate-d3

• Catalog No.: C369162
• M. F.: C25H31ClF2O5S
• M. W.: 517.0254464
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (1R,2S,8S,10S,11S,13R,14R,15S,17S)-14-{[(chloromethyl)sulfanyl]carbonyl}-1,8-difluoro-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-dien-14-yl (3,3,3-^2H₃)propanoate
• IUPAC Traditional name: (1R,2S,8S,10S,11S,13R,14R,15S,17S)-14-{[(chloromethyl)sulfanyl]carbonyl}-1,8-difluoro-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-dien-14-yl (3,3,3-^2H₃)propanoate
• Synonyms: 5-Chloromethyl 6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy-d3)-androsta-1,4-diene-17β-carbothioate; CCI 18773-d3; (6α.,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy-d3)androsta-1,4-diene-17-carbothioic Acid S-(Chloromethyl) Ester

PROPERTIES

• Solubility: Dichloromethane
• Solubility: DMF
• Solubility: Ethanol
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Apperance: Off-White to Pale Yellow Solid
• Melting Point: >214°C (dec.)
• Solubility: Chloroform
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

An intermediate in the synthesis of Fluticasone Propionate.

REFERENCES

• Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990)
• Mitchison, H.C., et al.: Gut, 32, 260 (1990)
• Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)