CHIR-98014

• Catalog No.: C292100
• CAS Number: 556813-39-9
• M. F.: C20H17Cl2N9O2
• M. W.: 486.31408
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 2-N-(2-{[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl]amino}ethyl)-5-nitropyridine-2,6-diamine
• IUPAC Traditional name: 2-N-(2-{[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl]amino}ethyl)-5-nitropyridine-2,6-diamine
• Synonyms: N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine

DATABASE IDS

• CAS Number: 556813-39-9

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: 192-196°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

A glycogen synthase kinase-3 (GSK-3) inhibitor. Effects of GSK inhibitors on p-tau, GSK-3β activities and cell death were measured in a human neuronal cell line (LUHMES). Lithium and CHIR98014 reduced tau phosphorylation (Ser396) in the cortex and hippoca

REFERENCES

• Aardema, M., et al.: Mutat. Res., 410, 3 (1998)
• Coghlan, M., et al.: Chem. Biol., 7, 793 (1998)
• Ring, D., et al.: Diabetes, 52, 588 (1998)
• Ougolkov, A., et al.: Cancer Res., 65, 2076 (1998)
• Armstrong, V., et al.: J. Biol. Chem., 282, 20715 (1998)
• Guo