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Chaetomellic Acid B Disodium Salt_Molecular_structure_CAS_)
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Chaetomellic Acid B Disodium Salt

Catalog No. C291830 Name Toronto Research Chemicals
CAS Number Website http://www.trc-canada.com
M. F. C21H34Na2O4 Telephone +1 (416) 665-9696
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SYNONYMS

IUPAC name
disodium (2Z)-2-[(7Z)-hexadec-7-en-1-yl]-3-methylbut-2-enedioate
IUPAC Traditional name
disodium (2Z)-2-[(7Z)-hexadec-7-en-1-yl]-3-methylbut-2-enedioate
Synonyms
(2Z)-2-(7Z)-7-Hexadecen-1-yl-3-methyl-2-butenedioic Acid Disodium Salt
(Z,Z)-2-(7-Hexadecenyl)-3-methyl-2-butenedioic Acid Disodium Salt
(2Z)-2-(7Z)-7-Hexadecenyl-3-methyl-2-butenedioic Acid Disodium Salt

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)
Chaetomellic acid B is an alkyl dicarboxylic acid isolated from the fermentation of Chaetomella acutiseta. Chaetomellic acid B has been shown to be a potent, highly specific inhibitor of RAS farnesyl protein transferase (FPTase). The association between RAS proteins and cancer has made Chaetomellic acid B a potential chemotherapeutic agent.

REFERENCES

  • Gibbs, J.B., et al.: J. Biol. Chem., 268, 7618 (1993)
  • Tamanoi, F., et al.: Trends Biochem. Sci., 18, 349 (1993)