C8 Ceramide

• Catalog No.: C262700
• CAS Number: 74713-59-0
• M. F.: C26H51NO3
• M. W.: 425.68804
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]octanamide
• IUPAC Traditional name: N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]octanamide
• Synonyms: N-Octanoyl-C18-sphingosine; D-erythro-N-Octanoylsphingosine; N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecenyl]octanamide; N-Octanoyl-D-erythro-sphingosine; N-Octanoylsphingosine; [R-[R*,S*-(E)]]-N-[2-Hydroxy-1-(hydroxymethyl)-3-heptadecenyl]octanamide

DATABASE IDS

• CAS Number: 74713-59-0

PROPERTIES

• Apperance: Off White Solid
• Melting Point: 68-70°C
• Solubility: Dichloromethane
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A biologically active, cell permeable, but nonphysiologic ceramide analog. It induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. It stimulates IL-2 secretion and induces apoptosis.

REFERENCES

• Mathias, S., et al.: Proc. Natl. Sci. USA, 88, 10009 (1991)
• Mathias, S., et al.: Science, 259, 519 (1991)
• Jarvis, W.D., et al.: Proc. Natl. Acad. Sci. USA, 91, 73 (1994)