C6 Ceramide-13C2,d2

• Catalog No.: C262602
• M. F.: C24H47NO3
• M. W.: 399.62018968
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: N-[(2R,3R,4E)-1,3-dihydroxy(1,2-^1^3C₂,1,1-^2H₂)octadec-4-en-2-yl]hexanamide
• IUPAC Traditional name: N-[(2R,3R,4E)-1,3-dihydroxy(1,2-^1^3C₂,1,1-^2H₂)octadec-4-en-2-yl]hexanamide
• Synonyms: Caproyl Ceramide-13C2,d2; N-Hexanoy-D-sphingosine-13C2,d2; N-Caproyl-D-sphingosine-13C2,d2

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 69-72°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A biologically active, cell permeable, but nonphysiologic ceramide analog. It stimulates protein phosphatase 2A at concentrations as low as 10 nM and activiates MAP kinase. It induces apoptosis and inhibits glycoproptein traffic by the secretory pathway

REFERENCES

• Dobrowsky, R.T., et al.: J. Biol. Chem., 268, 15523 (1993)
• Raines, M.A., et al.: J. Biol. Chem., 268, 14572 (1993)
• Jarvis, W.D., et al.: Proc. Natl. Acad. Sci. USA, 91, 73 (1993)