Celastrol

• Catalog No.: C249500
• CAS Number: 34157-83-0
• M. F.: C29H38O4
• M. W.: 450.60962

SYNONYMS

• IUPAC name: (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
• IUPAC Traditional name: triterpene
• Synonyms: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic Acid; 3-Hydroxy-2-oxo-24-nor-D:A-friedooleana-1(10),3,5,7-tetraen-29-oic Acid; Tripterin

DATABASE IDS

• CAS Number: 34157-83-0

PROPERTIES

• Apperance: Orange Red Solid
• Melting Point: 219-230°C
• Solubility: DMSO
• Solubility: Methanol

DETAILS

Description (English)

An antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be inhibito

REFERENCES

• Senger, D., et al.: Science, 219, 983 (1983)
• Folkman, J., et al.: Nature, 1, 27 (1983)
• He, W., et al.: Bioorg. Med. Chem. Lett., 8, 3659 (1983)
• Grosios, K., et al.: Inflamm. Res., 53, 133 (1983)
• Yang, H., et al.: Cancer Res., 66, 4758 (1983)