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Chaetomellic Acid A-d3 Disodium Salt_Molecular_structure_CAS_)
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Chaetomellic Acid A-d3 Disodium Salt

Catalog No. C291817 Name Toronto Research Chemicals
CAS Number Website http://www.trc-canada.com
M. F. C19H32Na2O4 Telephone +1 (416) 665-9696
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SYNONYMS

IUPAC name
disodium (2Z)-2-(2H3)methyl-3-tetradecylbut-2-enedioate
IUPAC Traditional name
disodium (2Z)-2-(2H3)methyl-3-tetradecylbut-2-enedioate
Synonyms
(2Z)-2-(Methyl-d3)-3-tetradecyl-2-butenedioic Acid Disodium Salt

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)
Labelled Chaetomellic Acid A (C291815). It is an alkyl dicarboxylic acid isolated from the fermentation of Chaetomella acutiseta. Chaetomellic acid A has been shown to be a potent, highly specific inhibitor of RAS farnesyl protein transferase (FPTase). The association between RAS proteins and cancer has made Chaetomellic acid A a potential chemotherapeutic agent.

REFERENCES

  • Gibbs, J.B., et al.: J. Biol. Chem., 268, 7618 (1993)
  • Tamanoi, F., et al.: Trends Biochem. Sci., 18, 349 (1993)