Carbovir-13C,d2 Triphosphate Triethylamine Salt

• Catalog No.: C177757
• M. F.: C17H31N6O11P3
• M. W.: 589.37557784

SYNONYMS

• IUPAC name: ({[({[(1S,4R)-4-[2-amino-6-oxo-6,9-dihydro(8-^1^3C)-3H-purin-9-yl]cyclopent-2-en-1-yl](^2H₂)methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid; triethylamine
• IUPAC Traditional name: ({[(1S,4R)-4-[2-amino-6-oxo(8-^1^3C)-3H-purin-9-yl]cyclopent-2-en-1-yl](^2H₂)methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxyphosphonic acid; triethylamine
• Synonyms: rel-P-[[(1R,4S)-4-(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)-2-cyclopenten-1-yl]methyl] Ester-13C,d2 Triphosphoric Acid Triethylamine Salt; (±)-Carbovir-13C,d2 Triphosphate Triethylamine Salt; cis-(±)-P-[[4-(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)-2-cyclopenten-1-yl]methyl] Ester-13C,d2 Triphosphoric Acid Triethylamine Salt

DETAILS

Description (English)

A labelled active metabolite of Abacavir (A104990) used to study the molecular mechanism of inhibition and drug resistance for HIV-1 reverse transcriptase.

REFERENCES

• Ray, A.S. et al.: Biochem., 41, 5150 (2002)
• Goicochea, M. et al.: J. Clin. Pharmacol., 50, 968 (2002)
• Hawkins, T. et al.: JAIDS, J. Acq. Imm. Defic. Synd., 39, 406 (2002)