Canadine

• Catalog No.: C175175
• CAS Number: 522-97-4
• M. F.: C20H21NO4
• M. W.: 339.38504

SYNONYMS

• IUPAC name: 16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0^2,^1^0.0^4,^8.0^1^5,^2^0]henicosa-2(10),3,8,15,17,19-hexaene
• IUPAC Traditional name: 16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0^2,^1^0.0^4,^8.0^1^5,^2^0]henicosa-2(10),3,8,15,17,19-hexaene
• Synonyms: (±)-Tetrahydroberberine; Tetrahydroberberine; 5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine; 9-Deoxy-16,17-dihydroberberine; 9,10-Dimethoxy-2,3-(methylenedioxy)berbine; (±)-Canadine; Tetrahydroberberine,; NSC 36351; NSC 94918; Tetrahydroumbellatine; Xanthopuccine; dl-Canadine; dl-Tetrahydroberberine

DATABASE IDS

• CAS Number: 522-97-4

DETAILS

Description (English)

Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling.

REFERENCES

• Duchowicz, P., et al.: Bioorg. Med. Chem., 14, 5876 (2006)
• Sun., et al.: Br. J. Pharmcol., 158, 1302 (2006)
• Deeb, O., et al.: Chem. Biol. Drug Des., 76, 255 (2006)