(S)-(+)-Camptothecin-d5

• Catalog No.: C175152
• M. F.: C20H16N2O4
• M. W.: 348.35204

SYNONYMS

• IUPAC name: (19S)-19-(^2H₅)ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• IUPAC Traditional name: (19S)-19-(^2H₅)ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• Synonyms: (S)-4-(Ethyl-d5)-4-hydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

DETAILS

Description (English)

Labelled (S)-(-)-Camptothecin (C175150). Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic anti

REFERENCES

• Potmesil, M., et al.: Cancer Res., 54, 1431 (1994)
• Desai, S.D., et al.: J. Biol. Chem., 272, 24159 (1994)
• Fan, Y., et al.: J. Med. Chem., 41, 2216 (1994)
• Kaufmann, S.H., et al.: Biochim. Biophys. Acta, 1400, 195 (1994)