Cabozantinib L-Malate Salt

• Catalog No.: C051500
• CAS Number: 1140909-48-3
• M. F.: C32H30FN3O10
• M. W.: 635.5931032
• Storage: Refrigerator

SYNONYMS

• IUPAC name: (2S)-2-hydroxybutanedioic acid; 1-N'-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• IUPAC Traditional name: (-)-malic acid; cabozantinib
• Synonyms: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (2S)-2-Hydroxybutanedioic Acid; XL 184; Cabozantinib S-Malate

DATABASE IDS

• CAS Number: 1140909-48-3

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 166-169°C
• Solubility: DMSO
• Storage Condition: Refrigerator

DETAILS

Description (English)

Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib sho

REFERENCES

• Wells, S., et al.: J. Clin. Oncol., 28, 767 (1999)
• Camp, R., et al.: Cancer, 86, 2259 (1999)
• Morello, S., et al.: J. Cell Physiol., 189, 285 (1999)
• Zhang, Y., et al.: Oncogene, 21, 217 (1999)