2'-O-(tert-Butyldimethylsilyl)-6α-hydroxy Paclitaxel

• Catalog No.: B691300
• CAS Number: 211732-86-4
• M. F.: C53H65NO15Si
• M. W.: 984.1664

SYNONYMS

• IUPAC name: (1S,2S,4S,7R,8S,9R,10S,12R,15S)-4,12-bis(acetyloxy)-15-{[(2R,3S)-2-[(tert-butyldimethylsilyl)oxy]-3-phenyl-3-(phenylformamido)propanoyl]oxy}-1,8,9-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^3,^1^0.0^4,^7]heptadec-13-en-2-yl benzoate
• IUPAC Traditional name: (1S,2S,4S,7R,8S,9R,10S,12R,15S)-4,12-bis(acetyloxy)-15-{[(2R,3S)-2-[(tert-butyldimethylsilyl)oxy]-3-phenyl-3-(phenylformamido)propanoyl]oxy}-1,8,9-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^3,^1^0.0^4,^7]heptadec-13-en-2-yl benzoate

DATABASE IDS

• CAS Number: 211732-86-4

PROPERTIES

• Apperance: White Solid
• Solubility: Chloroform
• Solubility: Dichloromethane
• Solubility: Ethyl Acetate
• Solubility: Methanol

DETAILS

Description (English)

6α-Hydroxypaclitaxel derivative.

REFERENCES

• Monsarrat, B., et al.: Drug Metab. Dispos., 18, 895 (1990)
• Walle, T., et al.: Biochem. Pharm., 46, 1661 (1990)
• Harris, J., et al.: J. Med. Chem., 37, 706 (1990)