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Brivanib Alaninate

Catalog No. B677640 Name Toronto Research Chemicals
CAS Number 649735-63-7 Website http://www.trc-canada.com
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SYNONYMS

IUPAC name
(2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-ol
IUPAC Traditional name
(2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-ol
Synonyms
BMS 582664
L-Alanine (1R)-2-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-1-methylethyl Ester

DATABASE IDS

CAS Number 649735-63-7

PROPERTIES

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DETAILS

Description (English)
A novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor. Antitumor agent.

REFERENCES

  • Ellis, L., et al.: Eur. J. Cancer, 32A, 2451 (1996)
  • Klagsbrun, M., et al.: Chem. Biol., 6, R217 (1996)
  • Auguste, P., et al.: Cancer Res., 61, 1717 (1996)
  • Bhide, R., et al.: J. Med. Chem., 49, 2143 (1996)