Brefeldin A

• Catalog No.: B677240
• CAS Number: 20350-15-6
• M. F.: C16H24O4
• M. W.: 280.35936
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (1R,6S,11aS,13S,14aR)-1,13-dihydroxy-6-methyl-1H,4H,6H,7H,8H,9H,11aH,12H,13H,14H,14aH-cyclopenta[f]oxacyclotridecan-4-one
• IUPAC Traditional name: brefeldin A
• Synonyms: Synergisidin; NSC 89671; Nectrolide; NSC 56310; γ-4-Dihdyroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic Acid, λ-Lactone, BFA, Cyanein, Ascotoxin, Decumbin; NSC 244390

DATABASE IDS

• CAS Number: 20350-15-6

PROPERTIES

• Apperance: White Solid
• Melting Point: 206-208°C
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis.

REFERENCES

• Misumi, Y., et al.: J. Biol. Chem., 261 (1986)
• Mordente, J.A., et al.: J. Urol., 159, 275 (1986)
• Erokhina, M.V., et al.: Membr. Cell Biol., 12, 871 (1986)
• Nojiri, H., et al.: FEBS Letters, 453, 140 (1986)