BMS 599626-d4

• Catalog No.: B596302
• M. F.: C27H27FN8O3
• M. W.: 530.5534832

SYNONYMS

• IUPAC name: (3S)-(5,5-^2H₂)morpholin-3-yl(^2H₂)methyl N-[4-({1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl}amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate
• IUPAC Traditional name: (3S)-(5,5-^2H₂)morpholin-3-yl(^2H₂)methyl N-[4-({1-[(3-fluorophenyl)methyl]indazol-5-yl}amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate
• Synonyms: AC 480-d4; N-[4-[[1-[(3-Fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic Acid (3S)-3-Morpholinylmethyl-d4 Ester

DETAILS

Description (English)

It is a highly selective and potent inhibitor of HER1 and HER2 kinases and inhibits tumor cell proliferation through modulation of receptor signaling. BMS-599626 inhibits HER1/HER2 receptor heterodimerization and provides an additional mechanism of inhib

REFERENCES

• Wiseman, L., et al.: Eur. J. Cancer, 29A, 2256 (1993)
• Wittman, M., et al.: J. Med. Chem., 48, 5639 (1993)
• Allen, G., et al.: Cancer Res., 67, 1155 (1993)