BMS 214662

• Catalog No.: B596050
• CAS Number: 195987-41-8
• M. F.: C25H23N5O2S2
• M. W.: 489.61242

SYNONYMS

• IUPAC name: (3R)-3-benzyl-1-(1H-imidazol-5-ylmethyl)-4-(thiophene-2-sulfonyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile
• IUPAC Traditional name: (3R)-3-benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophene-2-sulfonyl)-3,5-dihydro-2H-1,4-benzodiazepine-7-carbonitrile
• Synonyms: (3R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile; (R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile

DATABASE IDS

• CAS Number: 195987-41-8

DETAILS

Description (English)

A potent and selective inhibitor of farnesyltransferase that induces mitochondrial apoptosis in chronic myeloid leukemia stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cβ.

REFERENCES

• Rose, W.C. et al.: Cancer Res., 61, 7507 (2001)
• Tabernero, J. et al.: J. Clin. Oncol., 23, 2521 (2001)
• Pellicano, F. et al.: Blood, 114, 4186 (2001)