BLI 489 Hydrate

• Catalog No.: B595825
• CAS Number: 623564-40-9
• M. F.: C13H10N3NaO4S
• M. W.: 327.29097
• Storage: Refrigerator

SYNONYMS

• IUPAC name: sodium (5R)-6-{5H,6H,8H-imidazo[2,1-c][1,4]oxazin-3-ylmethylidene}-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
• IUPAC Traditional name: sodium (5R)-6-{5H,6H,8H-imidazo[2,1-c][1,4]oxazin-3-ylmethylidene}-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
• Synonyms: (5R,6Z)-6-[(5,6-Dihydro-8H-imidazo[2,1-c][1,4]oxazin-2-yl)methylene]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Sodium Salt Hydrate

DATABASE IDS

• CAS Number: 623564-40-9

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: >200°C (dec.)
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

BLI-489 is a penem β-lactamase inhibitor, which has shown activity against class A, C, and D β-lactamases. BLI-489 is being tested in combination therapy for drug-resistant bacteria.

REFERENCES

• Maiti, S., et al.: Curr. Med. Chem., 5, 441 (1998)
• Barnaud, G., et al.: Antimicrob. Agents Chemother., 48, 1040 (1998)
• Szabo, D., et al.: J. Clin. Microbiol., 43, 5058 (1998)