(S)-(-)-Blebbistatin

• Catalog No.: B592500
• CAS Number: 856925-71-8
• M. F.: C18H16N2O2
• M. W.: 292.33184
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (3aS)-3a-hydroxy-6-methyl-1-phenyl-1H,2H,3H,3aH,4H-pyrrolo[2,3-b]quinolin-4-one
• IUPAC Traditional name: (S)-blebbistatin
• Synonyms: (-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one; (-)-Blebbistatin; (3aS)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one

DATABASE IDS

• CAS Number: 856925-71-8

PROPERTIES

• Apperance: Bright Yellow Solid
• Melting Point: >205°C (dec.)
• Solubility: Chloroform
• Solubility: Dichloromethane
• Solubility: DMSO
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Blebbistatin also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. Blebbistatin blocks both blebbing and cytokinesis

REFERENCES

• Straight, A.F., et al.: Science, 299, 1743 (2003)
• Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2003)
• Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)