Bizelesin

• Catalog No.: B591700
• CAS Number: 129655-21-6
• M. F.: C43H36Cl2N8O5
• M. W.: 815.70254

SYNONYMS

• IUPAC name: 1,3-bis({2-[(1S)-1-(chloromethyl)-5-hydroxy-8-methyl-1H,2H,3H,6H-pyrrolo[3,2-e]indole-3-carbonyl]-1H-indol-5-yl})urea
• IUPAC Traditional name: 1,3-bis({2-[(1S)-1-(chloromethyl)-5-hydroxy-8-methyl-1H,2H,6H-pyrrolo[3,2-e]indole-3-carbonyl]-1H-indol-5-yl})urea
• Synonyms: NSC 615291; (8S,8'S)-6,6'-[Carbonylbis(imino-1H-indole-5,2-diylcarbonyl)]bis[8-(chloromethyl)-3,6,7,8-tetrahydro-1-methylbenzo[1,2-b:4,3-b']dipyrrol-4-ol; U 77779; N,N'-Bis[2-[[(1S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b']dipyrrol-3(2H)-yl]carbonyl]-1H-indol-5-yl]urea

DATABASE IDS

• CAS Number: 129655-21-6

DETAILS

Description (English)

As members of the cyclopropylpyrroloindole family, Adozelesin and Bizelesin cause genomic DNA lesions by alkylating DNA. Adozelesin induces single-strand DNA lesions, whereas Bizelesin induces both single-strand lesions and double-strand DNA cross-links.

REFERENCES

• Lee, C., et al.: Cancer Res., 51, 6586 (1991)
• McHugh, M., et al.: Biochemistry, 38, 11508 (1991)
• Liu, J., et al.: J. Biol. Chem., 275, 1391 (1991)