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2',7-Bis-O-(Triethylsilyl) 10-Desacetyl Paclitaxel_Molecular_structure_CAS_155556-72-2)
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2',7-Bis-O-(Triethylsilyl) 10-Desacetyl Paclitaxel

Catalog No. B585470 Name Toronto Research Chemicals
CAS Number 155556-72-2 Website http://www.trc-canada.com
M. F. C57H77NO13Si2 Telephone +1 (416) 665-9696
M. W. 1040.39118 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Chembase ID: 162429

SYNONYMS

IUPAC name
(1S,2S,3R,4S,7R,9R,10S,12R,15S)-4-(acetyloxy)-1,12-dihydroxy-10,14,17,17-tetramethyl-11-oxo-15-{[(2R,3S)-3-phenyl-3-(phenylformamido)-2-[(triethylsilyl)oxy]propanoyl]oxy}-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl benzoate
IUPAC Traditional name
(1S,2S,3R,4S,7R,9R,10S,12R,15S)-4-(acetyloxy)-1,12-dihydroxy-10,14,17,17-tetramethyl-11-oxo-15-{[(2R,3S)-3-phenyl-3-(phenylformamido)-2-[(triethylsilyl)oxy]propanoyl]oxy}-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl benzoate
Synonyms
(αR,βS)-(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-[(triethylsilyl)oxy]-benzenepropanoic Acid β-(Benzoylamino)-α-[(triethylsilyl)oxy]-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester

DATABASE IDS

CAS Number 155556-72-2

PROPERTIES

Certificate of Analysis Download
Apperance White Solid
Solubility Dichloromethane
MSDS Link Download

DETAILS

Description (English)
Protected Paclitaxel (P132500). An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sa

REFERENCES

  • Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984)
  • Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984)
  • Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1984)
  • Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (1984)
  • Stone, G.W., et al.: