Bisindolylmaleimide XI Hydrochloride

• Catalog No.: B448530
• M. F.: C28H29ClN4O2
• M. W.: 489.00846

SYNONYMS

• IUPAC name: 3-{8-[(dimethylamino)methyl]-6H,7H,8H,9H-pyrido[1,2-a]indol-10-yl}-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione hydrochloride
• IUPAC Traditional name: 3-{8-[(dimethylamino)methyl]-6H,7H,8H,9H-pyrido[1,2-a]indol-10-yl}-4-(1-methylindol-3-yl)-1H-pyrrole-2,5-dione hydrochloride
• Synonyms: Ro 31-0432; 3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Hydrochloride

DETAILS

Description (English)

Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and

REFERENCES

• Wilkinson, S.E. et al.: Biochem. J., 294, 335 (1993)
• Liu, Q., Chen, X. et al.: . Circ. Res. 105, 194 (1993)
• Birchall, A.M. et al.: J. Pharmacol. Exp. Ther., 268, 922 (1993)