4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole

• Catalog No.: B415890
• CAS Number: 210690-85-0
• M. F.: C30H57NO2SSi2
• M. W.: 552.01508

SYNONYMS

• IUPAC name: 4-[(1E,3S,5Z,10S)-3,11-bis[(tert-butyldimethylsilyl)oxy]-2,6,10-trimethylundeca-1,5-dien-1-yl]-2-methyl-1,3-thiazole
• IUPAC Traditional name: 4-[(1E,3S,5Z,10S)-3,11-bis[(tert-butyldimethylsilyl)oxy]-2,6,10-trimethylundeca-1,5-dien-1-yl]-2-methyl-1,3-thiazole
• Synonyms: 4-[(1E,3S,5Z,10S)-3,11-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,6,10-trimethyl-1,5-undecadien-1-yl]-2-methyl-thiazole

DATABASE IDS

• CAS Number: 210690-85-0

PROPERTIES

• Apperance: Colourless Oil
• Solubility: Chloroform
• Solubility: Dichloromethane
• Solubility: Ethanol
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Solubility: Toluene

DETAILS

Description (English)

An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical

REFERENCES

• Hoee, G., et al.: Pure Appl. Chem., 71, 11, 2019 (1999)
• Giannakakou, P., et al.: Proc. Natl. Acad. Sci. USA, 97, 2904 (2000)