(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid

• Catalog No.: B415725
• CAS Number: 193146-26-8
• M. F.: C39H71NO6SSi2
• M. W.: 738.22014

SYNONYMS

• IUPAC name: (3S,7R,8S,9S,12Z,15S,16E)-3,8-bis[(tert-butyldimethylsilyl)oxy]-15-hydroxy-4,4,7,9,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-6-oxoheptadeca-12,16-dienoic acid
• IUPAC Traditional name: (3S,7R,8S,9S,12Z,15S,16E)-3,8-bis[(tert-butyldimethylsilyl)oxy]-15-hydroxy-4,4,7,9,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-6-oxoheptadeca-12,16-dienoic acid
• Synonyms: [3S-(3R*,6S*,7R*,8R*,12Z,15R*,16E)]-3,7-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-4-thiazolyl)-5-oxo-12,16-heptadecadienoic Acid

DATABASE IDS

• CAS Number: 193146-26-8

PROPERTIES

• Apperance: Oil
• Solubility: Chloroform
• Solubility: Dichloromethane
• Solubility: Ethanol
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Solubility: Toluene

DETAILS

Description (English)

An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical

REFERENCES

• Hoee, G., et al.: Pure Appl. Chem., 71, 11, 2019 (1999)
• Giannakakou, P., et al.: Proc. Natl. Acad. Sci. USA, 97, 2904 (2000)