24,33-Bis-O-(tert-butyldimethylsilyl)-FK-506-13C, D2 (Major)

• Catalog No.: B415262
• M. F.: C56H97NO12Si2
• M. W.: 1033.53253484
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (1R,9S,12S,13S,14S,17R,18E,21S,23S,24R,25R,27R)-14-[(tert-butyldimethylsilyl)oxy]-12-[(1E)-1-[(1R,3S,4R)-4-[(tert-butyldimethylsilyl)oxy]-3-methoxycyclohexyl]prop-1-en-2-yl]-1-hydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-17-[(3-^1^3C,3,3-^2H₂)prop-2-en-1-yl]-11,28-dioxa-4-azatricyclo[22.3.1.0^4,^9]octacos-18-ene-2,3,10,16-tetrone
• IUPAC Traditional name: (1R,9S,12S,13S,14S,17R,18E,21S,23S,24R,25R,27R)-14-[(tert-butyldimethylsilyl)oxy]-12-[(1E)-1-[(1R,3S,4R)-4-[(tert-butyldimethylsilyl)oxy]-3-methoxycyclohexyl]prop-1-en-2-yl]-1-hydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-17-[(3-^1^3C,3,3-^2H₂)prop-2-en-1-yl]-11,28-dioxa-4-azatricyclo[22.3.1.0^4,^9]octacos-18-ene-2,3,10,16-tetrone
• Synonyms: 24,33-Bis-O-(tert-butyldimethylsilyl) Tacrolimus-13CD2

PROPERTIES

• Solubility: Ethyl Acetate
• Solubility: Methanol
• Apperance: Pale Yellow Solid
• Melting Point: 68-70°C
• Solubility: Chloroform
• Solubility: Dichloromethane
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

An intermediate in the preparation of labelled FK-506 (Tacrolimus)

REFERENCES

• Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996)
• Knoll, G.A., et al.: Brit. Med. J., 318, 1104 (1996)