Berberine Hydrochloride

• Catalog No.: B318150
• CAS Number: 633-65-8
• M. F.: C20H18ClNO4
• M. W.: 371.81422
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 16,17-dimethoxy-5,7-dioxa-13λ^5-azapentacyclo[11.8.0.0^2,^1^0.0^4,^8.0^1^5,^2^0]henicosa-1(21),2(10),3,8,13,15,17,19-octaen-13-ylium chloride
• IUPAC Traditional name: 16,17-dimethoxy-5,7-dioxa-13λ^5-azapentacyclo[11.8.0.0^2,^1^0.0^4,^8.0^1^5,^2^0]henicosa-1(21),2(10),3,8,13,15,17,19-octaen-13-ylium chloride
• Synonyms: 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium Chloride; Berberine Chloride; Berberine Hydrochloride; 7,8,13,13a-Tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium Chloride; NSC 646666

DATABASE IDS

• CAS Number: 633-65-8

PROPERTIES

• Apperance: Pale Yellow Solid
• Melting Point: 193-196°C (dec.)
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

An isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells. Also inhibits Activator Protein 1 (AP-1), a transcription

REFERENCES

• Zhang, X. et al.: Cancer Res., 70, 9895 (2010)
• Lin, H.L. et al.: Cancer 85, 1937(2010)
• Schumacher, M.A. et al.: Science, 294, 2158 (2010)
• Fukuda, K. et al.: J. Ethno., 66, 227(2010)