Bafetinib

• Catalog No.: B109050
• CAS Number: 859212-16-1
• M. F.: C30H31F3N8O
• M. W.: 576.6153496
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 4-{[(3R)-3-(dimethylamino)pyrrolidin-1-yl]methyl}-N-(4-methyl-3-{[4-(pyrimidin-5-yl)pyrimidin-2-yl]amino}phenyl)-3-(trifluoromethyl)benzamide
• IUPAC Traditional name: 4-{[(3R)-3-(dimethylamino)pyrrolidin-1-yl]methyl}-N-(4-methyl-3-{[4-(pyrimidin-5-yl)pyrimidin-2-yl]amino}phenyl)-3-(trifluoromethyl)benzamide
• Synonyms: INNO 406; NS 187; N-[3-([4,5'-Bipyrimidin]-2-ylamino)-4-methylphenyl]-4-[[(3S)-3-(dimethylamino)-1-pyrrolidinyl]methyl]-3-(trifluoromethyl)benzamide

DATABASE IDS

• CAS Number: 859212-16-1

PROPERTIES

• Apperance: Pale Yellow Solid
• Melting Point: 166-168°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

A substituted benzamide derivative structurally related to STI-571 (Imatinib Mesylate). It was identified as highly potent Bcr-Abl kinase inhibitor.

REFERENCES

• Li, Q., et al.: J. Med. Chem., 39, 3070 (1996)
• Ptasznik, A., et al.: Nat. Med., 10, 1187 (1996)
• Tetsuo, A., et al.: Bioorg. Med. Chem. Lett., 16, 1421 (1996)