Bacitracin Deuterated

• Catalog No.: B106502
• M. F.: C66H103N17O16S
• M. W.: 1422.69332

SYNONYMS

• IUPAC name: (4R)-4-[(2S)-2-({2-[(1S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazol-5-yl}formamido)-4-methylpentanamido]-4-{[(1S)-1-{[(3S,6R,9S,12R,15S,18R,21S)-18-(3-aminopropyl)-12-benzyl-15-(butan-2-yl)-3-(carbamoylmethyl)-6-(carboxymethyl)-9-(1H-imidazol-4-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclopentacosan-21-yl]carbamoyl}-2-methylbutyl]carbamoyl}butanoic acid
• IUPAC Traditional name: bacitracin A
• Synonyms: Baciguent-deuterated; Bacilliquin-deuterated; Tropitracin-deuterated; Bacillichin-deuterated; Parentracin-deuterated; N-[[(4R)-2-[(1S,2S)-1-Amino-2-methylbutyl]-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-α-glutamyl-L-isoleucyl-L-lysyl-D-ornithyl-L-isoleucyl-D-phenylalanyl-L-histidyl-D-α-aspartyl-L-asparagine (10→4)-Lactam Deuterated; Zutracin-deuterated; Altracin-deuterated; Ayfivin-deuterated; Fortracin-deuterated; Penitracin-deuterated; Topitracin-deuterated

DETAILS

Description (English)

Deuterated analogue of Bacitracin, a peptide antibiotic effective against gram-postive bacteria. Bacitracin is an inhibitor of peptidoglycan synthesis. Bacitracin disrupts bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphat

REFERENCES

• Ward, J.B. et al.: Biochem. J., 141, 227 (1974)
• Anastasi, A. et al.: Biochem. J., 290, 601 (1974)
• Daly, D.J. et al.: Biochem. Soc. Trans., 13, 1161 (1974)
• Weinberg, E.D. et al.: Antibiot. Ber., 90, (1974)